I am a Professor of Computer Science, Statistical Science, and Biology at Duke University. I direct the Program in Computational Biology and Bioinformatics and am an active member of the Duke Center for Genomic and Computational Biology and the Duke Center for Systems Biology. I have been at Duke since September 2001, when I received my Ph.D. from the Department of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology under the supervision of David Gifford, Tommi Jaakkola, and Rick Young.
Generally, my research interests are in computational systems biology and machine learning. Specifically, my work focuses on the development and application of new statistical learning algorithms to complex problems in systems biology. I am especially, but not exclusively, interested in:
- mapping out networks of transcriptional regulation,
- revealing mechanisms behind control of the eukaryotic cell cycle,
- reconstructing accurate protein-protein and domain-domain interaction networks,
- understanding how information flows in the brain during sensory processing and learning tasks,
- identifying imprinted genes, their regulatory mechanisms, and their implications for disease, and
- improving the diagnosis and treatment of disease using high-throughput clinical data.
Although these problems are quite diverse, a number of common themes appear repeatedly throughout my work: probabilistic representations, Bayesian statistics, fusion of information from multiple sources, optimization of joint objective functions, and learning in high-dimensional spaces without over-fitting. Many of these themes are variations on two simple ideas: careful attention to biology in the development of statistical models and the use of informative Bayesian priors to both regularize and guide automated learning.
Prof. Alexander J. Hartemink
Department of Computer Science
mailing address: Computer Science, Box 90129, Durham NC 27708-0129
package address: 308 Research Drive, LSRC D239, Durham NC 27708
office location: LSRC Building, Room D239
tel: (919) 660-6514
fax: (919) 660-6519
email: amink at cs.duke.edu